
Michael Polansky — better known publicly as Lady Gaga's partner and a former top deputy to Sean Parker — has quietly spent years building an AI-driven startup that keeps living human skin tissue alive for weeks outside the body to discover new skincare compounds, and is only now going public about it.
Will Polansky's AI skincare startup announce a named commercial product or licensing deal by December 31?
Resolves by Dec 31, 2026
A startup is training AI models on human skin tissue that remains alive outside the body for extended periods. The company sources skin that would otherwise be discarded after surgery through vetted biobanks operating under institutional review board oversight and documented donor consent, then uses a proprietary support system to keep the tissue viable for up to a month, far longer than the industry standard of a few days. This matters because scientists currently lack ethical ways to test drugs and treatments directly on people, so they rely on poor substitutes like animal models and simplified cell cultures, whereas living human tissue could better represent how the body actually responds to treatments. The extended viability enables testing of slower biological processes like collagen remodeling and pigmentation change that take weeks to develop, rather than just acute toxicity that can be measured in days.

Runable says 60%–70% of its 1 trillion-plus token usage in the last 90 days came from paying customers.

Discover how loveholidays uses OpenAI Codex to make software development accessible across the business, helping teams turn ideas into products faster.

Perplexity has released Portable Computer, a local-first build of its agentic Computer platform that runs the agent harness, orchestrator, planner, tool router and post-trained models directly on NVIDIA DGX Spark. The local model, inference engine, tool sandbox and app connectors ship as one packaged system, every task begins on the device, and work handled by local models carries no per-token charge. When a step needs the live web or frontier reasoning, the orchestrator stops and asks before s
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