Google DeepMind model predicts DNA effects on cells
The Verge: Google’s AlphaGenome 2 zooms in on the cellular roots of disease
A graphic representing Google’s AlphaGenome Atlas. | Image: Google Researchers at Google DeepMind have unveiled a new AI model designed to unravel how changes in our DNA affect different cells, giving scientists a more detailed view of a notoriously difficult problem that could hold important clues to the causes of disease - and point the way to new treatments. AlphaGenome 2 is the successor to DeepMind's genome-predicting AI model AlphaGenome, which was released last year. Whil
Google DeepMind has developed a new AI model that predicts how changes in DNA affect different types of cells in the human body. While nearly every cell carries the same DNA, different cell types switch genes on and off in different patterns, so the same genetic variant can have very different effects depending on the cell type and state. The model was trained on more than 100 million individual cell profiles across 68 tissues and identifies nearly twice as many variants that can change gene expression compared to previous models. This specificity matters for drug development because treatments target specific proteins in specific cell types, making this detailed view of how genetic variants affect individual cells potentially valuable for understanding disease causes and finding new treatments.
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Also reported by The Verge, SiliconANGLE and MarkTechPost
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